Description

9-Bromo-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1188331-74-9. This compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly within medicinal chemistry research and development. It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in the discovery and development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the development of potential APIs for various therapeutic areas.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines where required.

Basic Information

Product Name	9-Bromo-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride
CAS No.	1188331-74-9
Molecular Formula	C₁₃H₁₈BrCl₂N₂
Molecular Weight	354.10 g/mol
Synonyms	9-Bromo-1,2,3,4,6,7-hexahydro-11bH-pyrazino[2,1-a]isoquinoline dihydrochloride; 9-Bromo-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline dihydrochloride; 9-Bromo-1,2,3,4,6,7-hexahydro-11bH-pyrazino[2,1-a]isoquinoline hydrochloride (1:2); 1188331-74-9; 9-Br-HHPIQ dihydrochloride
EINECS	Contact for details

Quality Control

Our 9-Bromo-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.