Description

Tizanidine-D4 is a deuterium-labeled analog of the skeletal muscle relaxant Tizanidine, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and bioanalytical fields who require precise quantification of Tizanidine in complex matrices like biological fluids and pharmaceutical formulations.

Application

• Primary use as an internal standard for the quantification of Tizanidine in bioanalytical studies using LC-MS/MS.
• Essential component in pharmacokinetic and metabolism research to study the absorption, distribution, and excretion of Tizanidine.
• Critical for therapeutic drug monitoring (TDM) assays to ensure accurate patient dosing and safety.
• Used in pharmaceutical quality control for the precise assay of Tizanidine in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Valuable in forensic and clinical toxicology for the definitive identification and measurement of Tizanidine.
• Supports method development and validation in analytical laboratories to meet regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	Tizanidine-D4
CAS No.	1188331-19-2
Molecular Formula	C₉H₄D₄ClN₅S
Molecular Weight	257.74 g/mol (for deuterated form)
Synonyms	5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine-d4; 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole-d4; Tizanidine (phenyl-d4); Tizanidine-d4 Internal Standard; [²H₄]-Tizanidine; Lioresal-d4; Sirdalud-d4; Zanaflex-d4
EINECS	Contact for details

Quality Control

Every batch of Tizanidine-D4 is manufactured and tested to meet the stringent requirements for stable isotope-labeled internal standards. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure high chemical and isotopic purity. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay, isotopic enrichment, and impurity profile to support your regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.