Description

3-(Methoxy-D3)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazin-2-Amine is a high-value, deuterated boronic ester derivative, a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise synthesis of complex molecules, particularly for applications requiring isotopic labeling or Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of deuterated drug candidates, enhancing metabolic stability and pharmacokinetic profiles.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boronic ester reagent for constructing biaryl and heterobiaryl structures central to many active pharmaceutical ingredients (APIs).
• Isotope Labeling Studies: The deuterated methoxy group (Methoxy-D3) is utilized in mass spectrometry and NMR-based metabolic and mechanistic studies.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with potentially improved properties.
• Material Science: Used in the creation of organic electronic materials, such as those for OLEDs and semiconductors, where specific pyrazine structures are valuable.
• Chemical Biology & Proteomics: Serves as a handle for bioconjugation or as a component in probe molecules for target identification.

Basic Information

Product Name	3-(Methoxy-D3)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazin-2-Amine
CAS No.	1188298-74-9
Molecular Formula	C11H19D3BN3O3
Molecular Weight	252.15 g/mol
Synonyms	2-Amino-3-(methoxy-d3)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trideuteriomethoxy)pyrazin-2-amine; 3-(Methoxy-d3)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrazinamine; Deuterated Pinacol Boronate Pyrazine Amine; (2-Amino-6-(methoxy-d3)pyrazin-3-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(Methoxy-D3)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazin-2-Amine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment (D3), and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.