Description

Verapamil-D7 Hydrochloride is a high-purity, deuterium-labeled internal standard essential for modern analytical chemistry. This stable isotope-labeled compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and reproducible results.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of verapamil and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in preclinical and clinical research.
• Drug Metabolism and Disposition (DMPK): Used in metabolite profiling and identification studies to differentiate drug-derived compounds from endogenous substances.
• Method Development and Validation: A key component in developing and validating robust, regulatory-compliant analytical methods for pharmaceutical quality control.
• Forensic and Clinical Toxicology: Assists in the accurate measurement of verapamil levels in forensic investigations or therapeutic drug monitoring.
• Reference Material for Certified Standards: Acts as a primary material for manufacturers of certified reference materials (CRMs).

Basic Information

Product Name	Verapamil-D7 Hydrochloride
CAS No.	1188265-55-5
Molecular Formula	C27H31D7ClN2O4 • HCl
Molecular Weight	~ 507.1 g/mol
Synonyms	Verapamil-d7 HCl; (±)-Verapamil-d7 hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile-d7 hydrochloride; 2-Isopropyl-2-(3,4-dimethoxyphenyl)-5-[methyl(2-(3,4-dimethoxyphenyl)ethyl)amino]valeronitrile-d7 hydrochloride; Isoptin-d7 hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenepropanenitrile-d7 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Verapamil-D7 Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity (HPLC assay), isotopic enrichment, and residual solvents. Our quality commitment supports compliance with GLP and GMP principles for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.