Description

10-Bromo-2-Methyl-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1188264-49-4. This compound is a critical building block in modern medicinal chemistry, valued for its complex heterocyclic structure which serves as a key scaffold in drug discovery and development. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Used in route scouting and scale-up studies for the efficient and cost-effective production of candidate drugs.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation of related drug substances.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and synthesizing novel chemical libraries.
• Contract Research & Manufacturing (CRO/CMO): A critical raw material for organizations providing custom synthesis and development services to the global pharmaceutical industry.

Basic Information

Product Name	10-Bromo-2-Methyl-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride
CAS No.	1188264-49-4
Molecular Formula	C₁₄H₂₀BrCl₂N₂
Molecular Weight	368.13 g/mol
Synonyms	10-Bromo-2-methyl-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline dihydrochloride; 10-Bromo-2-methyl-1,2,3,4,6,7,11b-octahydropyrazino[2,1-a]isoquinoline dihydrochloride; 1188264-49-4; Pyrazino[2,1-a]isoquinoline, 10-bromo-2-methyl-2,3,4,6,7,11b-hexahydro-, dihydrochloride; 10-Bromo-2-methyl-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinoline hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our 10-Bromo-2-Methyl-2,3,4,6,7,11B-Hexahydro-1H-Pyrazino[2,1-A]Isoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and process development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (IR, NMR), and impurity profile is provided with every shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and desiccated to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.