Description

4-(3-Bromophenyl)-2-Chlorothiazole is a high-purity halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific bromophenyl and chlorothiazole motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly those targeting kinase inhibition or other biological pathways where the thiazole core is pharmacologically relevant.
• Agrochemical Synthesis: Serves as a precursor for creating new herbicides, fungicides, or insecticides, leveraging the bioactivity of the halogenated thiazole structure.
• Material Science Research: Used in the synthesis of organic semiconductors, ligands for catalysis, or photoactive materials due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes or tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromine and chlorine atoms present orthogonal reactivity, making it a valuable substrate for sequential Suzuki, Stille, or Buchwald-Hartwig amination reactions.
• Library Synthesis for HTS: A valuable building block for generating diverse compound libraries used in high-throughput screening (HTS) campaigns in drug discovery.

Basic Information

Product Name	4-(3-Bromophenyl)-2-Chlorothiazole
CAS No.	1188037-87-7
Molecular Formula	C9H5BrClNS
Molecular Weight	274.56 g/mol
Synonyms	2-Chloro-4-(3-bromophenyl)thiazole; 4-(3-Bromophenyl)-2-chloro-1,3-thiazole; 3-Bromo-α-(2-chloro-4-thiazolyl)benzene; 2-Chloro-4-(m-bromophenyl)thiazole; (3-Bromophenyl)-2-chlorothiazole; 4-(3-Bromophenyl)-2-chlorothiazole; 1188037-87-7
EINECS	Contact for details

Quality Control

Our 4-(3-Bromophenyl)-2-Chlorothiazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and GC-MS for solvent residue analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable local and international regulations for chemical substances.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.