Description

3(R)-Aminomethyl-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride is a high-purity chiral amine derivative, primarily utilized as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical agents, particularly those targeting the central nervous system. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this material for constructing complex molecular architectures with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic molecules.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in catalytic and stoichiometric asymmetric reactions.
• Chemical Biology: Employed in the design and synthesis of molecular probes for studying biological systems and enzyme function.
• Ligand Development: A precursor for creating novel ligands in catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	3(R)-Aminomethyl-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride
CAS No.	1187932-47-3
Molecular Formula	C10H16N2·2HCl
Molecular Weight	237.17 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-3-(aminomethyl)isoquinoline dihydrochloride; (3R)-1,2,3,4-Tetrahydro-3-(aminomethyl)isoquinoline dihydrochloride; (R)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride; 3(R)-Aminomethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 3R-ATIQ·2HCl; 3R-AMTIQ·2HCl; (R)-Tetrahydropapaverine derivative
EINECS	Contact for details

Quality Control

Our 3(R)-Aminomethyl-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.