Description

(R)-(1,2,3,4-Tetrahydroisoquinolin-3-Yl)Methanamine is a chiral amine building block of significant importance in modern organic synthesis and pharmaceutical research. Its value lies in its rigid, fused bicyclic structure, which serves as a key scaffold for constructing complex molecules with potential biological activity. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, enzyme inhibitors, and receptor modulators.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Development: Serves as a building block for novel pesticides and herbicides, leveraging its bioactive core structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Process Chemistry & Scale-up: Investigated for route scouting and optimization in the pilot-scale manufacturing of advanced intermediates.

Basic Information

Product Name	(R)-(1,2,3,4-Tetrahydroisoquinolin-3-Yl)Methanamine
CAS No.	1187932-41-7
Molecular Formula	C10H14N2
Molecular Weight	162.23 g/mol
Synonyms	(R)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline; (R)-1,2,3,4-Tetrahydro-3-isoquinolinemethanamine; (R)-TIC Amine; (R)-3-Aminomethyl-1,2,3,4-tetrahydroisoquinoline; (R)-TIQMA; (R)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline; (R)-1,2,3,4-Tetrahydroisoquinoline-3-methanamine
EINECS	Contact for details

Quality Control

Our (R)-(1,2,3,4-Tetrahydroisoquinolin-3-Yl)Methanamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.