Description

(S)-3-Aminomethyl-2-Fmoc-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a high-purity, chiral building block specifically designed for advanced pharmaceutical synthesis. This compound is critical for researchers and process chemists developing novel therapeutic agents, particularly in peptide and peptidomimetic chemistry. Its primary value lies in enabling the controlled introduction of the (S)-1,2,3,4-tetrahydroisoquinoline scaffold, a privileged structure in medicinal chemistry, under Fmoc-protected conditions. This product is essential for R&D and production within the pharmaceutical, biotechnology, and fine chemical sectors focused on drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Peptidomimetic Drug Discovery: Used to incorporate rigid, constrained amino acid analogs into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative in Fmoc-based SPPS protocols for constructing complex peptides and peptide libraries.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in asymmetric catalytic reactions to construct complex molecules with high enantiomeric purity.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of chemical probes, enzyme inhibitors, and labeled compounds for mechanistic and target engagement studies.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality starting point for the development and optimization of scalable synthetic routes for clinical and commercial drug manufacturing.

Basic Information

Product Name	(S)-3-Aminomethyl-2-Fmoc-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride
CAS No.	1187932-12-2
Molecular Formula	C26H25N2O2 • HCl
Molecular Weight	424.95 g/mol
Synonyms	(S)-2-((9H-Fluoren-9-yl)methoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-methanamine hydrochloride; Fmoc-3-Aminomethyl-Tic-OH.HCl; (S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride; (S)-N-Fmoc-3-aminomethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (S)-2-Fmoc-3-aminomethyl-1,2,3,4-tetrahydroisoquinoline HCl; Fmoc-Tic(3-CH2NH2)-OH • HCl
EINECS	Contact for details

Quality Control

Our (S)-3-Aminomethyl-2-Fmoc-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.