Description

(S)-3-Aminomethyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid Benzyl Ester is a high-purity chiral building block of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a key intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecules, leveraging its defined stereochemistry and functional groups to streamline synthesis pathways and ensure product efficacy.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and cardiovascular targets.
• Peptidomimetic Chemistry: Used in the design and synthesis of peptide analogs and protease inhibitors, where the isoquinoline scaffold provides structural rigidity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral centers into complex molecular architectures.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and lead optimization processes within pharmaceutical and biotech laboratories.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates under cGMP conditions.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and chemical biology.

Basic Information

Product Name	(S)-3-Aminomethyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid Benzyl Ester
CAS No.	1187932-04-2
Molecular Formula	C18H18N2O2
Molecular Weight	294.35 g/mol
Synonyms	Benzyl (S)-3-(aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate; (S)-2-(Benzyloxycarbonyl)-3-(aminomethyl)-1,2,3,4-tetrahydroisoquinoline; (S)-N-Cbz-3-Aminomethyl-1,2,3,4-tetrahydroisoquinoline; (S)-3-(Aminomethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester; (S)-3-(Aminomethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid phenylmethyl ester; (S)-TIQ-3-CH2NH2-CBz; Chiral Isoquinoline Derivative
EINECS	Contact for details

Quality Control

Our (S)-3-Aminomethyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid Benzyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment, supporting regulatory submissions and cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.