Description

(R)-n-(4-Nitrophenyl)-Tryptophan is a specialized chiral amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate for the synthesis of novel, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing enzyme inhibitors, receptor ligands, and other therapeutic agents where stereochemistry is paramount. Its unique structure, incorporating both a tryptophan scaffold and a nitrophenyl group, makes it valuable for probing biological interactions and creating targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate reaction mechanisms and enzyme specificity.
• Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships (SAR) and to enhance peptide stability or binding affinity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthetic routes to create complex molecules with high enantiomeric purity.
• Proteomics & Molecular Biology: Useful as a tagged amino acid analog for labeling proteins or for use in activity-based protein profiling (ABPP).
• Material Science Research: Potential building block for designing novel chiral organic frameworks or functional materials with specific optical properties.

Basic Information

Product Name	(R)-n-(4-Nitrophenyl)-Tryptophan
CAS No.	1187930-30-8
Molecular Formula	C19H17N3O4
Molecular Weight	351.36 g/mol
Synonyms	(R)-2-Amino-3-(1H-indol-3-yl)-N-(4-nitrophenyl)propanamide; (R)-α-Amino-1H-indole-3-propanoic acid N-(4-nitrophenyl)amide; D-N-(4-Nitrophenyl)tryptophan; (R)-N-(4-Nitrophenyl)tryptophan; (R)-Tryptophan, N-(4-nitrophenyl)-; 1H-Indole-3-propanoic acid, α-amino-, (αR)-, N-(4-nitrophenyl)amide
EINECS	Contact for details

Quality Control

Our (R)-n-(4-Nitrophenyl)-Tryptophan is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral assay, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications. Our quality commitment supports applications requiring high levels of enantiomeric excess and chemical purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.