Description

1-(4-Fluoro-Benzyl)-2-Piperazin-1-Yl-1H-Benzoimidazole Dihydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant interest in pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel antiviral and potentially other therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly within the antiviral and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of advanced non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral applications.
• Biochemical Research: Used as a reference standard and active compound in biochemical assays to study enzyme inhibition and mechanism of action.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs for novel drug discovery.
• Antiviral Drug Development: A key scaffold for research into new treatments targeting retroviruses and other viral pathogens.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for pharmacological and virological studies.

Basic Information

Product Name	1-(4-Fluoro-Benzyl)-2-Piperazin-1-Yl-1H-Benzoimidazole Dihydrochloride
CAS No.	1187930-00-2
Molecular Formula	C18H20Cl2FN5
Molecular Weight	396.29 g/mol
Synonyms	1-[(4-Fluorophenyl)methyl]-2-(1-piperazinyl)-1H-benzimidazole dihydrochloride; 1-(4-Fluorobenzyl)-2-(piperazin-1-yl)-1H-benzoimidazole dihydrochloride; 2-(Piperazin-1-yl)-1-(4-fluorobenzyl)-1H-benzoimidazole dihydrochloride; BILR 355 BS Dihydrochloride; BILR 355 BS (dihydrochloride); NNRTI Intermediate BILR 355; R165335 Dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-Fluoro-Benzyl)-2-Piperazin-1-Yl-1H-Benzoimidazole Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.