Description

(S)-n-(4-Nitro-Phenyl)-L-Tryptophan CAS NO 1187929-73-2 is a high-purity, non-natural amino acid derivative featuring a chiral tryptophan core modified with a 4-nitrophenyl group. This compound is a critical chiral building block and intermediate in advanced pharmaceutical research and development, particularly for the synthesis of targeted therapeutics. It is essential for medicinal chemists and process development scientists working in drug discovery, especially for applications involving enzyme inhibitors, receptor modulators, and proteolysis-targeting chimeras (PROTACs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used as a building block for constructing complex molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetic Development: Incorporated into peptide analogs and mimetics to enhance stability, bioavailability, and target binding affinity.
• Biochemical Probe Synthesis: Utilized in the creation of labeled compounds and probes for studying biological pathways and enzyme mechanisms.
• Asymmetric Synthesis Catalyst: Can be employed as a precursor or ligand in the development of chiral catalysts for enantioselective transformations.

Basic Information

Product Name	(S)-n-(4-Nitro-Phenyl)-L-Tryptophan
CAS No.	1187929-73-2
Molecular Formula	C19H17N3O4
Molecular Weight	351.36 g/mol
Synonyms	(S)-N-(4-Nitrophenyl)tryptophan; L-Tryptophan, N-(4-nitrophenyl)-; (S)-N-(4-Nitrophenyl)-L-tryptophan; N-(4-Nitrophenyl)-L-tryptophan; (2S)-2-Amino-3-[1H-indol-3-yl]-N-(4-nitrophenyl)propanamide; 1187929-73-2; (S)-N-(4-Nitro-Phenyl)-L-Tryptophan
EINECS	Contact for details

Quality Control

Our (S)-n-(4-Nitro-Phenyl)-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.