Description

5-Iodo-2,3-Dihydro-1H-Indole Hydrochloride is a high-purity, halogenated indoline derivative used as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and the development of novel pharmaceutical candidates, particularly in the areas of kinase inhibitors and central nervous system (CNS) active agents. It is primarily utilized by R&D chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to introduce iodine functionality into complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Chemical Biology Probes: Serves as a starting material for creating labeled compounds or probes for biological target identification.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents and herbicides.
• Material Science: Building block for advanced organic materials and functional polymers.

Basic Information

Product Name	5-Iodo-2,3-Dihydro-1H-Indole Hydrochloride
CAS No.	1187928-16-0
Molecular Formula	C8H9IN2·HCl
Molecular Weight	296.53 g/mol
Synonyms	5-Iodoindoline Hydrochloride; 5-Iodo-2,3-dihydro-1H-indole HCl; 1H-Indole, 5-iodo-2,3-dihydro-, hydrochloride; 5-Iodoindoline Hydrochloride Salt; 5-Iodo-2,3-dihydroindole Hydrochloride; 5-Iodoindoline HCl; 5-Iodo-1H-indoline Hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available upon request for every batch, detailing identity, purity, and impurity profiles to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.