Description

Methyl 7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-Isoquinolin-5-Carboxylate Hcl is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, especially within the central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• API Synthesis: Serves as a precursor in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.
• Process Chemistry Development: Used in scaling up and optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	Methyl 7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-Isoquinolin-5-Carboxylate Hydrochloride
CAS No.	1187830-67-6
Molecular Formula	C12H12F3NO2•HCl
Molecular Weight	295.68 g/mol (Free base: 259.23 g/mol)
Synonyms	5-Carbomethoxy-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; Methyl 7-(trifluoromethyl)-5-isoquinolinecarboxylate hydrochloride (1,2,3,4-tetrahydro); 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid methyl ester hydrochloride; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)-5-isoquinolinecarboxylic acid methyl ester HCl; CAS 1187830-67-6
EINECS	Contact for details

Quality Control

Our production of Methyl 7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-Isoquinolin-5-Carboxylate Hcl adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects with material suitable for use under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.