Description

7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-Isoquinolin-5-Carbonitrile Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl-substituted tetrahydroisoquinoline core. This compound is of significant commercial value for its role in streamlining the synthesis of complex bioactive molecules, offering a critical building block for medicinal chemistry research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the biological activity of the isoquinoline structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-Isoquinolin-5-Carbonitrile Hcl
CAS No.	1187830-66-5
Molecular Formula	C11H10F3N2•HCl
Molecular Weight	260.66 g/mol (Free base: 224.21 g/mol)
Synonyms	5-Cyano-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 7-(Trifluoromethyl)-5-cyano-1,2,3,4-tetrahydroisoquinoline HCl; 7-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline-5-carbonitrile hydrochloride; 7-(Trifluoromethyl)-1,2,3,4-tetrahydro-5-isoquinolinecarbonitrile hydrochloride; 1187830-66-5; 5-CN-7-CF3-THIQ•HCl
EINECS	Contact for details

Quality Control

Our production of 7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-Isoquinolin-5-Carbonitrile Hcl adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.