Description

7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-5-Iodo-Isoquinoline Hcl CAS NO 1187830-65-4 is a high-purity, advanced pharmaceutical intermediate featuring a unique halogenated isoquinoline scaffold. This compound is valued for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to the presence of both trifluoromethyl and iodine groups, which are valuable for modulating lipophilicity, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides, where the halogenated isoquinoline core can impart specific biological activity.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Employed in university and institutional labs for fundamental organic synthesis methodology development and exploring new chemical spaces.

Basic Information

Product Name	7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-5-Iodo-Isoquinoline Hydrochloride
CAS No.	1187830-65-4
Molecular Formula	C10H10F3IN·HCl
Molecular Weight	373.56 g/mol
Synonyms	5-Iodo-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 7-(Trifluoromethyl)-5-iodo-1,2,3,4-tetrahydroisoquinoline HCl; 5-Iodo-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-5-iodo-7-(trifluoromethyl)isoquinoline hydrochloride; 7-Trifluoromethyl-5-iodo-1,2,3,4-tetrahydroisoquinoline HCl salt; 1187830-65-4 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of 7-(Trifluoromethyl)-1,2,3,4-Tetrahydro-5-Iodo-Isoquinoline Hcl is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with comprehensive control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting full compliance with agreed specifications. We support development and cGMP-grade production with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.