Description

8A-(Trifluoromethyl)Hexahydropyrrolo[1,2-A]Pyrimidin-6(7H)-One is a high-value, advanced pharmaceutical intermediate featuring a unique fused pyrrolopyrimidinone scaffold with a strategically positioned trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering significant potential for modulating the pharmacokinetic and binding properties of novel drug candidates. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of bioactive molecules, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its privileged heterocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed as a component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: A valuable precursor for developing potent and selective kinase inhibitors, leveraging the pyrrolopyrimidinone core.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	8A-(Trifluoromethyl)Hexahydropyrrolo[1,2-A]Pyrimidin-6(7H)-One
CAS No.	1187570-21-3
Molecular Formula	C9H11F3N2O
Molecular Weight	220.19 g/mol
Synonyms	8a-(Trifluoromethyl)hexahydro-1H-pyrrolo[1,2-a]pyrimidin-6(7H)-one; Hexahydro-8a-(trifluoromethyl)pyrrolo[1,2-a]pyrimidin-6(7H)-one; 8a-Trifluoromethylhexahydropyrrolo[1,2-a]pyrimidin-6-one; 1H-Pyrrolo[1,2-a]pyrimidin-6(7H)-one, hexahydro-8a-(trifluoromethyl)-; 8a-(Trifluoromethyl)perhydropyrrolo[1,2-a]pyrimidin-6-one
EINECS	Contact for details

Quality Control

Our production of 8A-(Trifluoromethyl)Hexahydropyrrolo[1,2-A]Pyrimidin-6(7H)-One adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. Our quality system is designed to support both non-GMP and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.