Description

4-(3-Chloro-2-Fluorophenyl)-2-Methylbut-3-Yn-2-Ol is a high-value fluorinated and chlorinated aromatic alkyne derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both halogen substituents and a tertiary propargylic alcohol functional group, makes it an indispensable building block for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the halogenated phenyl ring contributes to biological activity.
• Material Science Research: Serves as a monomer or precursor for specialty polymers, liquid crystals, and organic electronic materials due to its rigid, halogenated aromatic core.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags, leveraging the alkyne group for click chemistry applications like CuAAC reactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Product Name	4-(3-Chloro-2-Fluorophenyl)-2-Methylbut-3-Yn-2-Ol
CAS No.	1187385-72-3
Molecular Formula	C11H10ClFO
Molecular Weight	212.65 g/mol
Synonyms	2-Methyl-4-(3-chloro-2-fluorophenyl)but-3-yn-2-ol; 4-(3-Chloro-2-fluorophenyl)-2-methyl-3-butyn-2-ol; 3-Butyn-2-ol, 4-(3-chloro-2-fluorophenyl)-2-methyl-; 2-Methyl-4-(3-chloro-2-fluorophenyl)-3-butyn-2-ol; 1187385-72-3; 3-Chloro-2-fluorophenyl propargyl alcohol derivative
EINECS	Contact for details

Quality Control

Our production of 4-(3-Chloro-2-Fluorophenyl)-2-Methylbut-3-Yn-2-Ol adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our facility operates under cGMP principles suitable for pharmaceutical intermediate production, ensuring reliable supply and traceability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage under an inert atmosphere (nitrogen or argon), please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.