Description

3-Formyl-6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile is a high-value, multi-functional indole derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its molecular architecture, featuring both formyl and nitrile groups on a trifluoromethylated indole scaffold, makes it an exceptionally versatile building block for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, where the trifluoromethyl group is prized for its ability to enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Material Science: Serves as a monomer or functional unit in the research of advanced organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology: Employed as a probe or labeling agent due to its reactive aldehyde and nitrile functionalities for bioconjugation and activity-based protein profiling.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in university and CRO laboratories focused on heterocyclic and fluorine chemistry.

Basic Information

Product Name	3-Formyl-6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile
CAS No.	1186404-95-4
Molecular Formula	C11H5F3N2O
Molecular Weight	238.17 g/mol
Synonyms	5-Cyano-6-(trifluoromethyl)-1H-indole-3-carboxaldehyde; 6-(Trifluoromethyl)-1H-indole-5-carbonitrile-3-carboxaldehyde; 3-Formyl-6-trifluoromethyl-1H-indole-5-carbonitrile; 1H-Indole-5-carbonitrile, 3-formyl-6-(trifluoromethyl)-; 6-Trifluoromethyl-1H-indole-3-carbaldehyde-5-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Formyl-6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material typically meets a purity specification of ≥97% (HPLC), with stringent control over related substances and residual solvents. A detailed Certificate of Analysis (COA) providing full chromatographic and spectroscopic data (HPLC, GC, NMR, MS) is supplied with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.