Description

3-Bromo-6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile is a high-value, multi-functional indole derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring bromine and trifluoromethyl substituents on the indole core, makes it indispensable for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, receptor modulators, and other biologically active molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group often enhances bioavailability and metabolic stability.
• Material Science: Serves as a monomer or functional component in the creation of specialty polymers, organic semiconductors, and advanced materials with specific optoelectronic properties.
• Chemical Synthesis: Acts as a versatile scaffold for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) or nucleophilic substitutions, enabling library synthesis for high-throughput screening.
• Fluorine Chemistry: An important reagent for introducing fluorine-containing motifs into target molecules, a common strategy in modern medicinal chemistry to improve potency and ADME profiles.

Basic Information

Product Name	3-Bromo-6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile
CAS No.	1186404-83-0
Molecular Formula	C10H4BrF3N2
Molecular Weight	289.05 g/mol
Synonyms	5-Cyano-3-bromo-6-(trifluoromethyl)-1H-indole; 1H-Indole-5-carbonitrile, 3-bromo-6-(trifluoromethyl)-; 3-Bromo-6-trifluoromethyl-1H-indole-5-carbonitrile; 3-Bromo-6-(trifluoromethyl)indole-5-carbonitrile; 1186404-83-0; AKOS026714023; ZINC000095049772; BRN 15328267
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile is manufactured and tested under strict quality management systems to ensure consistency and reliability for your research and development processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.