Description

6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its indole core, nitrile group, and trifluoromethyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where it introduces desirable properties like metabolic stability and enhanced lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates targeting oncology, CNS disorders, and inflammatory diseases.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or labeling reagent due to the indole scaffold.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile
CAS No.	1186404-61-4
Molecular Formula	C10H5F3N2
Molecular Weight	210.16 g/mol
Synonyms	5-Cyano-6-(trifluoromethyl)-1H-indole; 6-(Trifluoromethyl)-1H-indole-5-carbonitrile; 1H-Indole-5-carbonitrile, 6-(trifluoromethyl)-; 6-Trifluoromethyl-1H-indole-5-carbonitrile; 5-CN-6-CF3-1H-Indole
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-1H-Indole-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.