Description

1,5-Dihydro-2H-Azeto[3,2-E]Indole-2,6-Dicarboxylic Acid 2-(tert-Butyl) 6-Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused-ring heterocyclic structure. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought after by research institutions, custom synthesis houses, and pharmaceutical companies engaged in the development of new chemical entities and complex generics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing intricate indole- and azetidine-based frameworks during lead optimization and structure-activity relationship (SAR) studies.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial R&D labs for exploring new synthetic methodologies and heterocyclic chemistry.
• Custom Manufacturing: Supplied to contract development and manufacturing organizations (CDMOs) for the production of bespoke compounds and non-commercial scale APIs under cGMP guidelines.
• Process Chemistry: Used in the development and scale-up of efficient synthetic routes for potential new drugs, where the tert-butyl and methyl ester protecting groups offer strategic advantages.

Basic Information

Product Name	1,5-Dihydro-2H-Azeto[3,2-E]Indole-2,6-Dicarboxylic Acid 2-(tert-Butyl) 6-Methyl Ester
CAS No.	1186194-95-5
Molecular Formula	C18H21NO4
Molecular Weight	315.36 g/mol
Synonyms	2-(tert-Butyl) 6-methyl 1,5-dihydro-2H-azeto[3,2-e]indole-2,6-dicarboxylate; Azeto[3,2-e]indole-2,6-dicarboxylic acid, 1,5-dihydro-, 2-(1,1-dimethylethyl) 6-methyl ester; 1,5-Dihydro-2H-azeto[3,2-e]indole-2,6-dicarboxylic acid 2-tert-butyl ester 6-methyl ester; CAS 1186194-95-5; tert-Butyl methyl azetoindoledicarboxylate; Fused azetidine-indole diester intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up work. Certificates of Analysis (COA) are provided with each shipment, detailing purity, identity, and impurity profiles. Quality is verified using modern analytical techniques including HPLC, GC, NMR, and mass spectrometry. While typically supplied as a high-purity R&D grade, we can discuss production under cGMP conditions for projects requiring regulatory filing support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maximize stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.