Description

(1S,4S)-2-Thia-5-Azabicyclo[2.2.1]Heptane 2,2-Dioxide is a high-purity, advanced pharmaceutical intermediate featuring a unique, conformationally restricted bicyclic sulfonamide scaffold. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates with enhanced target selectivity and metabolic stability. It is primarily needed by research and development teams in the pharmaceutical and biotechnology industries for the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Scaffold: Used to construct conformationally constrained analogs in structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a core structural motif in the design of inhibitors for various protease enzymes.
• Chemical Biology Probe Synthesis: Employed in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines.
• Contract Research & Manufacturing (CRAM): A critical raw material for organizations providing custom synthesis and development services.

Basic Information

Product Name	(1S,4S)-2-Thia-5-Azabicyclo[2.2.1]Heptane 2,2-Dioxide
CAS No.	1186058-73-0
Molecular Formula	C5H9NO2S
Molecular Weight	147.20 g/mol
Synonyms	(1S,4S)-2-Thia-5-azabicyclo[2.2.1]heptane 2,2-dioxide; (1S,4S)-2-Thia-5-azabicyclo[2.2.1]heptane S,S-dioxide; endo-(1S,4S)-2-Thia-5-azabicyclo[2.2.1]heptane 2,2-dioxide; (1S,4S)-2-Thia-5-azabicyclo[2.2.1]heptane-2,2-dione; (1S,4S)-Bicyclic Sulfonamide; (1S,4S)-2,5-Diaza-3-thiabicyclo[2.2.1]heptane 3,3-dioxide (alternative numbering); (1S,4S)-2-Thia-5-azabicyclo[2.2.1]heptane-2,2-dioxide; (1S,4S)-2-Thia-5-azabicyclo[2.2.1]heptane-2,2-diol S,S-dioxide
EINECS	Contact for details

Quality Control

Our (1S,4S)-2-Thia-5-Azabicyclo[2.2.1]Heptane 2,2-Dioxide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, and custom specifications aligned with cGMP principles can be supported for advanced development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.