Description

5-Bromo-6-Fluoro-1-Methyl-1H-Indazole is a high-purity, advanced pharmaceutical intermediate with a distinct halogenated indazole structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapies. It is primarily required by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors and other small-molecule therapeutics.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a starting material or intermediate in scalable API synthesis routes.
• Biochemical Research: Employed as a probe or ligand in biochemical assays to study enzyme function and cellular pathways.
• Custom Synthesis: A foundational compound for the custom manufacturing of specialized fluorinated and brominated heterocycles.

Basic Information

Product Name	5-Bromo-6-Fluoro-1-Methyl-1H-Indazole
CAS No.	1185767-06-9
Molecular Formula	C8H6BrFN2
Molecular Weight	229.05 g/mol
Synonyms	5-Bromo-6-fluoro-1-methylindazole; 1-Methyl-5-bromo-6-fluoro-1H-indazole; 1H-Indazole, 5-bromo-6-fluoro-1-methyl-; 1185767-06-9; 5-Bromo-6-fluoro-1-methylindazole; 5-Br-6-F-1-Me-1H-indazole
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-Fluoro-1-Methyl-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.