Description

2-Hydroxy-4-(Methyl-D3)-Pyridine is a deuterium-labeled derivative of 4-methyl-2-pyridinol, featuring a deuterated methyl group at the 4-position. This stable isotope-labeled compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway elucidation. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery, pharmacokinetic studies, and mass spectrometry-based analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference standard in quantitative bioanalysis for drug and metabolite quantification in biological matrices.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of parent compounds and identify metabolites.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug development.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate and precise measurements in clinical research and environmental analysis.
• Synthesis of Deuterated Drug Candidates: Acts as a key building block for synthesizing deuterated analogs of active pharmaceutical ingredients (APIs) to potentially enhance metabolic stability.
• Proteomics and Biomarker Research: Facilitates relative and absolute quantification in complex proteomic studies.

Basic Information

Product Name	2-Hydroxy-4-(Methyl-D3)-Pyridine
CAS No.	1185316-03-3
Molecular Formula	C6H4D3NO
Molecular Weight	114.14 g/mol
Synonyms	4-(Trideuteriomethyl)-2-pyridinol; 4-(Methyl-d3)-2-pyridinol; 2-Hydroxy-4-(trideuteriomethyl)pyridine; 2-Pyridinol, 4-(methyl-d3)-; Deuterated 4-Methyl-2-hydroxypyridine; 4-(CD3)-2-Hydroxypyridine; 2-Hydroxy-4-(methyl-d3)pyridine; 4-Methyl-d3-pyridin-2-ol
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-4-(Methyl-D3)-Pyridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocols are designed to meet the stringent requirements of research and development. A comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity (D-content), and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.