Description

2-Bromo-5-Methoxypyridine-D3 is a deuterium-labeled isotopologue of 2-bromo-5-methoxypyridine, a valuable halogenated pyridine derivative. This compound is specifically designed for use as a stable isotope-labeled internal standard in quantitative analytical methods, ensuring superior accuracy and reliability in mass spectrometry. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for drug metabolism and pharmacokinetics (DMPK) studies, as well as in the synthesis of labeled target molecules.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Essential in pharmaceutical R&D for tracing metabolic pathways, assessing bioavailability, and conducting absorption, distribution, metabolism, and excretion (ADME) research.
• Synthetic Intermediate: Acts as a deuterium-labeled building block for the synthesis of more complex isotopically labeled compounds in medicinal chemistry.
• Agrochemical Research: Used in environmental fate studies and residue analysis of pyridine-based agrochemicals.
• Forensic and Clinical Toxicology: Enables accurate measurement of specific analytes or metabolites in diagnostic and forensic testing.

Basic Information

Product Name	2-Bromo-5-Methoxypyridine-D3
CAS No.	1185315-90-5
Molecular Formula	C6H3D3BrNO
Molecular Weight	190.04 g/mol (deuterated)
Synonyms	2-Bromo-5-methoxy-d3-pyridine; 5-Methoxy-2-bromopyridine-d3; (2-Bromo-5-methoxypyridin-3,4,6-d3); Deuterated 2-Bromo-5-methoxypyridine; 2-Bromo-5-methoxypyridine (trideuterated); 2-Bromo-5-(methyl-d3-oxy)pyridine; Bromo-methoxy-d3-pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Methoxypyridine-D3 is produced and tested under strict quality management protocols to ensure the highest isotopic and chemical purity for research applications. Our standard specifications include verification of deuterium incorporation (D-enrichment) by NMR and mass spectrometry, alongside standard identity and purity assays. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and solvent residues is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (D-enrichment)	≥ 98 atom % D (by MS or 1H NMR)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.