Description

2-Bromo-4-(Methyl-D3)-Pyridine is a deuterium-labeled derivative of 2-bromo-4-methylpyridine, where three hydrogen atoms in the methyl group are replaced by deuterium. This isotopic labeling is critical for creating internal standards in quantitative mass spectrometry, enhancing analytical accuracy and reliability. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for drug metabolism and pharmacokinetics (DMPK) studies, where precise tracking of molecular pathways is required.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering reference compound for the accurate quantification of its non-deuterated counterpart in bioanalytical assays.
• Pharmaceutical Research & Development: Used as a key deuterated intermediate in the synthesis of isotopically labeled drug candidates for metabolism and mechanism of action studies.
• Agrochemical Research: Employed in the development and environmental fate studies of deuterated pesticide and herbicide analogs.
• Metabolite Identification: Aids in the identification and structural elucidation of metabolites in complex biological matrices.
• Chemical Biology Probes: Utilized to create tagged molecular probes for tracking biochemical interactions and pathways.
• Process Chemistry & Scale-up: Acts as a specialized intermediate for the production of deuterated active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	2-Bromo-4-(Methyl-D3)-Pyridine
CAS No.	1185311-65-2
Molecular Formula	C6H3D3BrN
Molecular Weight	176.03 g/mol
Synonyms	2-Bromo-4-(trideuteriomethyl)pyridine; 4-(Methyl-d3)-2-bromopyridine; 2-Bromo-4-methyl-d3-pyridine; Deuteronated 2-Bromo-4-methylpyridine; Pyridine, 2-bromo-4-(methyl-d3)-; 2-Br-4-(CD3)-Pyridine; 2-Bromo-4-(methyl-2H3)pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Methyl-D3)-Pyridine is produced under strict quality management systems to ensure high isotopic purity and chemical integrity, which are paramount for analytical applications. Each batch is characterized by advanced spectroscopic techniques including NMR, HPLC, and GC-MS to confirm structure, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (D%), chemical purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.