Description

2-Amino-5-(Methyl-D3)-Pyridine is a deuterium-labeled derivative of 2-amino-5-methylpyridine, a valuable building block in synthetic organic chemistry. This isotopically labeled compound is essential for creating internal standards and labeled analogs used in advanced analytical and metabolic studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require high-purity, stable-isotope labeled materials for drug discovery, development, and quantification.

Application

• Pharmaceutical Research & Development: Serves as a key deuterated intermediate in the synthesis of isotopically labeled drug candidates for pharmacokinetic (PK), pharmacodynamic (PD), and mass spectrometry studies.
• Metabolite Identification & Tracing: Used to synthesize internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to accurately quantify drug metabolites and study metabolic pathways.
• Agrochemical Development: Employed in the creation of deuterated analogs of pesticides and herbicides for environmental fate studies and residue analysis.
• Analytical Chemistry: Critical for preparing calibration standards in bioanalytical methods, enhancing the accuracy and reliability of quantitative assays.
• Chemical Biology & Proteomics: Can be incorporated into probes or tags for studying protein-ligand interactions and cellular processes using techniques like SILAC (Stable Isotope Labeling by Amino acids in Cell culture).
• Material Science Research: Potential use in the synthesis of specialized deuterated polymers or organic electronic materials where isotopic substitution modifies physical properties.

Basic Information

Product Name	2-Amino-5-(Methyl-D3)-Pyridine
CAS No.	1185311-13-0
Molecular Formula	C6H4D3N2
Molecular Weight	113.15 g/mol
Synonyms	2-Amino-5-(trideuteriomethyl)pyridine; 5-(Methyl-d3)-2-pyridinamine; 2-Pyridinamine, 5-(trideuteriomethyl)-; Deuterated 2-Amino-5-methylpyridine; 2-Amino-5-(CD3)-pyridine; 2-Amino-5-methyl-d3-pyridine; (Methyl-d3)-2-aminopyridine; 5-(Trideuteromethyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(Methyl-D3)-Pyridine is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, which is critical for research and analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by NMR or MS), and identity confirmation. We are committed to supplying materials that meet the stringent requirements of GMP and ISO guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D, NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.