Description

4-(Trideuteriomethyl)-1,3-Thiazol-2-Amine CAS NO 1185306-90-4 is a deuterated derivative of the heterocyclic compound 2-aminothiazole, where three hydrogen atoms in the methyl group are replaced with deuterium. This isotopic labeling is critical for applications requiring enhanced analytical precision and metabolic stability studies. It serves as a valuable building block and internal standard in pharmaceutical research and development, particularly for drug discovery and analytical chemistry.

Application

• Pharmaceutical Research & Development: As a deuterated building block for synthesizing isotopically labeled drug candidates to study pharmacokinetics, metabolic pathways, and bioavailability.
• Analytical Chemistry & Mass Spectrometry: Used as a stable isotope-labeled internal standard for the accurate quantification of its non-deuterated counterpart or related metabolites in complex biological matrices via LC-MS/MS.
• Metabolic Stability Studies: Employed in tracer studies to investigate the metabolic fate of thiazole-containing compounds, leveraging the kinetic isotope effect (KIE) to slow down specific metabolic reactions.
• Medicinal Chemistry: A key intermediate for creating deuterated analogs of bioactive molecules aimed at improving drug properties such as half-life and reducing unwanted metabolite formation.
• Biochemical Research: Utilized in mechanistic studies to probe enzyme-substrate interactions and reaction mechanisms involving methyl group transformations.
• Contract Research Organizations (CROs): Supplied to CROs specializing in drug metabolism and pharmacokinetics (DMPK) studies for client projects.

Basic Information

Item	Detail
Product Name	4-(Trideuteriomethyl)-1,3-Thiazol-2-Amine
CAS No.	1185306-90-4
Molecular Formula	C4H3D3N2S
Molecular Weight	118.17 g/mol
Synonyms	2-Amino-4-(trideuteriomethyl)thiazole; 4-(Trideuteromethyl)-2-thiazolamine; 2-Amino-4-(methyl-d3)thiazole; 4-(Methyl-d3)-1,3-thiazol-2-amine; 4-(Methyl-d3)-2-aminothiazole; Deuterated 2-Amino-4-methylthiazole; 2-Amino-4-(CD3)-thiazole; 1185306-90-4
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure high isotopic purity and chemical integrity, essential for research accuracy. Each batch is characterized by advanced spectroscopic and chromatographic methods. Certificates of Analysis (COA) are provided, detailing key parameters such as chemical purity, isotopic enrichment (D atom %), and impurity profiles. We support compliance with relevant GLP (Good Laboratory Practice) standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture and contamination. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D atom %)	≥ 98.0% (by 1H-NMR or MS)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.