Description

2-Bromo-5-(Methyl-D3)-Pyridine is a deuterated pyridine derivative, specifically labeled at the methyl group, which serves as a crucial stable isotope-labeled building block. This compound is valued for its use in advanced research and development, particularly in mechanistic studies and as an internal standard in analytical chemistry. It is primarily needed by pharmaceutical researchers, agrochemical developers, and contract research organizations (CROs) engaged in drug discovery, metabolism studies, and the synthesis of novel labeled compounds.

Application

• Pharmaceutical Research & Development: As a deuterium-labeled intermediate in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for drug discovery programs, particularly for metabolism and pharmacokinetic (DMPK) studies.
• Analytical Chemistry Standard: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of related compounds in complex matrices.
• Agrochemical Development: Serves as a key synthon in the research and synthesis of new, labeled agrochemicals and pesticides for environmental fate and metabolic pathway tracing.
• Metabolite Identification & Tracing: Employed in mechanistic studies to trace metabolic pathways and identify metabolites due to the kinetic isotope effect (KIE) of the deuterium label.
• Material Science Research: Potential use as a precursor in the development of advanced organic electronic materials and ligands for catalysis where isotopic labeling is beneficial.
• Contract Research & Custom Synthesis: A vital building block for CROs and CDMOs offering custom synthesis services for labeled compounds to the global life sciences market.

Basic Information

Product Name	2-Bromo-5-(Methyl-D3)-Pyridine
CAS No.	1185306-03-9
Molecular Formula	C6H3D3BrN
Molecular Weight	172.03 g/mol
Synonyms	2-Bromo-5-(trideuteriomethyl)pyridine; 5-(Methyl-d3)-2-bromopyridine; 2-Bromo-5-(methyl-d3)pyridine; Pyridine, 2-bromo-5-(methyl-d3)-; 2-Bromo-5-(CD3)-pyridine; Deutero-labeled 2-Bromo-5-methylpyridine; (Methyl-d3)-2-bromopyridine; 2-Bromo-5-(trideuteromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Methyl-D3)-Pyridine is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, critical for research integrity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC/GC), isotopic enrichment (by NMR/MS), and identity confirmation. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97% (Chemical Purity)
Isotopic Enrichment (NMR / MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.