Description

3-(1H-Benzoimidazol-2-Yl)-1,2,2-Trimethyl-Cyclopentanecarboxylic Acid Hydrochloride is a high-purity, non-racemic chiral building block of significant interest in advanced pharmaceutical synthesis. This compound matters because it provides a structurally complex, functionalized cyclopentane core essential for creating novel, biologically active molecules with high stereochemical fidelity. Pharmaceutical R&D and process chemistry teams need it for the development of new drug candidates, particularly in therapeutic areas requiring sophisticated small-molecule modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used in constructing core scaffolds for potential inhibitors targeting various protease enzymes.
• Kinase Modulator Development: Serves as a building block for novel compounds designed to modulate kinase activity in oncology and inflammatory diseases.
• Asymmetric Synthesis: Employed in stereoselective chemical reactions to introduce complex molecular architecture.
• Medicinal Chemistry Research: Utilized in lead optimization and structure-activity relationship (SAR) studies during drug discovery.
• Chemical Biology Probes: Acts as a precursor for labeled or tagged molecules used to study biological pathways and target engagement.

Basic Information

Product Name	3-(1H-Benzoimidazol-2-Yl)-1,2,2-Trimethyl-Cyclopentanecarboxylic Acid Hydrochloride
CAS No.	1185300-27-9
Molecular Formula	C16H21N2O2 • HCl
Molecular Weight	324.81 g/mol (Free base: 273.35 g/mol)
Synonyms	3-(1H-Benzo[d]imidazol-2-yl)-1,2,2-trimethylcyclopentanecarboxylic acid hydrochloride; 3-(1H-Benzoimidazol-2-yl)-1,2,2-trimethylcyclopentane-1-carboxylic acid hydrochloride; 3-(1H-Benzimidazol-2-yl)-1,2,2-trimethylcyclopentanecarboxylic acid HCl; (1R,3S)-3-(1H-Benzoimidazol-2-yl)-1,2,2-trimethylcyclopentanecarboxylic acid hydrochloride (enantiomer); Cyclopentanecarboxylic acid, 3-(1H-benzimidazol-2-yl)-1,2,2-trimethyl-, hydrochloride; 1185300-27-9
EINECS	Contact for details

Quality Control

Our 3-(1H-Benzoimidazol-2-Yl)-1,2,2-Trimethyl-Cyclopentanecarboxylic Acid Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.