Description

Methyl 1-(4-Fluorobenzyl)-1H-Indazole-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1185287-50-6. This compound is a critical building block in modern medicinal chemistry, valued for its indazole core and fluorinated benzyl moiety which are essential for modulating biological activity and pharmacokinetic properties. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent, targeted small-molecule drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize lead compounds for efficacy and safety.
• Oncology Drug Development: Serves as a core scaffold for developing kinase inhibitors and other anticancer agents.
• CNS-Active Compound Synthesis: Employed in creating candidates for treating neurological disorders.
• Chemical Biology Probes: Utilized to develop tool compounds for studying specific biological pathways and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.

Basic Information

Product Name	Methyl 1-(4-Fluorobenzyl)-1H-Indazole-3-Carboxylate
CAS No.	1185287-50-6
Molecular Formula	C16H13FN2O2
Molecular Weight	284.29 g/mol
Synonyms	Methyl 1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxylate; 1-(4-Fluorobenzyl)-1H-indazole-3-carboxylic acid methyl ester; 1H-Indazole-3-carboxylic acid, 1-[(4-fluorophenyl)methyl]-, methyl ester; 1185287-50-6; Methyl 1-(4-fluorobenzyl)indazole-3-carboxylate; 1-(4-Fluorobenzyl)indazole-3-methyl carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 1-(4-Fluorobenzyl)-1H-Indazole-3-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality system is designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.