Description

Clovoxamine-D3 is a deuterium-labeled analog of the selective serotonin reuptake inhibitor (SSRI) clovoxamine, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of clovoxamine and its metabolites in complex biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of clovoxamine.
• Bioanalytical Method Development and Validation: Essential for developing, validating, and ensuring the robustness of high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assays.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports accurate measurement of drug concentrations in patient samples during clinical trials and routine TDM.
• Forensic and Toxicology Analysis: Aids in the definitive identification and quantification of clovoxamine in forensic investigations.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability-indicating assay methods for pharmaceutical formulations.

Basic Information

Product Name	Clovoxamine-D3
CAS No.	1185246-59-6
Molecular Formula	C19H20D3ClFN3O2
Molecular Weight	Contact for details
Synonyms	Clovoxamine-d3; Deuterated Clovoxamine; 5-[(4-Chloro-2-fluorophenyl)methyl]-4-(methyl-d3)-2-oxo-1,3-oxazolidine-3-carboxamide; (4R,5S)-5-[(4-Chloro-2-fluorophenyl)methyl]-4-(trideuteriomethyl)-1,3-oxazolidin-2-one-3-carboxamide; DUOMOX-d3; FE-20100-d3
EINECS	Contact for details

Quality Control

Every batch of Clovoxamine-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (typically ≥99 atom % D), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % D
Chemical Purity	≥99%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.