Description

Fluvoxamine-D3 is a deuterated isotopologue of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine, specifically labeled with three deuterium atoms. This compound is an essential internal standard for the precise quantification of fluvoxamine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research to ensure data accuracy and regulatory compliance.

Application

• Internal Standard for Bioanalysis: Serves as a critical reference compound in the quantitative analysis of fluvoxamine in plasma, serum, and other biological samples via mass spectrometry.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Drug Impurity Profiling and Characterization: Used as a marker in method development and validation for identifying and quantifying related substances.
• Forensic and Toxicology Testing: Supports accurate measurement of fluvoxamine levels in forensic investigations and toxicological screenings.
• Quality Control in Pharmaceutical Manufacturing: Applied in analytical methods to ensure the potency and purity of fluvoxamine active pharmaceutical ingredient (API) and finished dosage forms.
• Stable Isotope Labeling Research: Utilized in mechanistic studies to investigate metabolic pathways and degradation products.

Basic Information

Item	Detail
Product Name	Fluvoxamine-D3
CAS No.	1185245-56-0
Molecular Formula	C15H18D3F3N2O2
Molecular Weight	Approx. 318.33 g/mol
Synonyms	Fluvoxamine-d3; (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-2-Aminoethyl-d3 Oxime; Fluvoxamine (D3); Deuterated Fluvoxamine; Fluvoxamine Internal Standard; 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl-d3) oxime; Luvox-d3
EINECS	Contact for details

Quality Control

Our Fluvoxamine-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS analysis, to confirm isotopic purity, chemical purity, and structural identity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the stringent requirements for use as an internal standard in regulated bioanalytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0% D3
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.