Description

Rac All-Trans 3-Hydroxyretinal-D5 is a deuterated isotopologue of 3-hydroxyretinal, a key chromophore in visual pigments and microbial rhodopsins. This compound is essential for advanced research in photobiology and vision science, where isotopic labeling is required for precise metabolic tracing, structural elucidation via NMR, and mechanistic studies of photoisomerization. It is a critical reagent for pharmaceutical and biotechnology R&D teams focused on retinal protein engineering, photodynamic therapy, and the development of novel optogenetic tools.

Application

• Biochemical Research: Used as a stable isotope-labeled internal standard for the quantitative analysis of retinoids and their metabolites via LC-MS/MS.
• Photobiology Studies: Essential for investigating the photocycle and function of microbial rhodopsins, including bacteriorhodopsin and channelrhodopsins.
• Vision Science: Employed in mechanistic studies of the visual cycle, particularly in tracing the metabolism and isomerization of retinal derivatives.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development of therapies targeting retinal diseases.
• Optogenetics: Used in the engineering and characterization of light-sensitive proteins for neural control and cellular signaling applications.
• Metabolic Pathway Analysis: Facilitates detailed mapping of retinoid uptake, conversion, and degradation pathways in biological systems.

Basic Information

Product Name	Rac All-Trans 3-Hydroxyretinal-D5
CAS No.	1185245-26-4
Molecular Formula	C20H23D5O2
Molecular Weight	301.45 g/mol
Synonyms	3-Hydroxyretinal-d5; all-trans-3-Hydroxyretinal-d5; 3,4-Didehydroretinol-d5 derivative; Vitamin A aldehyde-d5; Retinene-d5; (2E,4E,6E,8E)-3-Hydroxy-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal-d5; Deuterated 3-Hydroxyretinal; Isotopically Labeled Retinal Chromophore
EINECS	Contact for details

Quality Control

Every batch of Rac All-Trans 3-Hydroxyretinal-D5 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below to minimize oxidation and degradation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange solid or oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 90%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.