Description

Mycophenolic Acid-D3 is a stable isotope-labeled analog of the active metabolite of the immunosuppressant mycophenolate mofetil. This high-purity deuterated standard is essential for ensuring accuracy and reliability in quantitative bioanalytical studies. It is primarily used by pharmaceutical researchers and contract research organizations (CROs) for method development, validation, and pharmacokinetic analysis.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the precise quantification of mycophenolic acid in biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioequivalence Studies: Enables accurate tracking of drug concentration over time in clinical trials for immunosuppressive therapies.
• Therapeutic Drug Monitoring (TDM): Used in assay development to monitor mycophenolic acid levels in transplant patients to optimize dosage and minimize toxicity.
• Metabolite Profiling and Research: Facilitates research into the metabolism and disposition of mycophenolate drugs.
• Method Development and Validation: Provides a stable, non-interfering reference point for developing robust and compliant analytical methods (e.g., following FDA/EMA guidelines).
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and assay verification of mycophenolate drug substances and products.

Basic Information

Product Name	Mycophenolic Acid-D3
CAS No.	1185242-90-3
Molecular Formula	C17H17D3O6
Molecular Weight	323.35 g/mol
Synonyms	6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-5-isobenzofuranyl)-4-methyl-4-hexenoic-2,2,3-d3 Acid; (E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic-2,2,3-d3 Acid; Mycophenolate Acid-d3; MPA-d3; Deuterated Mycophenolic Acid; [2,2,3-2H3]-Mycophenolic Acid
EINECS	Contact for details

Quality Control

Our Mycophenolic Acid-D3 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry for isotopic purity and HPLC for chemical purity, to ensure it meets the exacting standards required for analytical research. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and solvent content are provided.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity	≥ 95.0% (by HPLC)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.