Description

n-Desmethyl Droloxifene-D5 CAS NO 1185241-63-7 is a deuterated internal standard critical for ensuring analytical accuracy in quantitative bioanalysis. This high-purity compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) methods, providing superior precision and reliability for pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D and clinical laboratories focused on the development and monitoring of selective estrogen receptor modulators (SERMs) and related therapeutics.

Application

• Primary use as a deuterated internal standard (IS) for the precise quantification of Droloxifene and its metabolites in biological matrices via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for SERM-based drug candidates.
• Enables accurate drug metabolism and disposition (DMPK) research, aiding in metabolite profiling and identification.
• Supports clinical trial analysis for monitoring drug levels in patient plasma, serum, or urine samples.
• Facilitates method development and validation in regulatory-compliant bioanalytical laboratories.
• Used in forensic and anti-doping analysis for the detection and confirmation of specific pharmaceutical agents.

Basic Information

Product Name	n-Desmethyl Droloxifene-D5
CAS No.	1185241-63-7
Molecular Formula	C26H20D5NO3
Molecular Weight	~407.5 g/mol
Synonyms	3-Hydroxytamoxifen-d5; Droloxifene-d5 Metabolite; (E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-butene-3-ol-d5; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene-d5; Droloxifene N-Desmethyl-d5; n-Desmethyl Droloxifene Deuterated Standard
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Droloxifene-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, HPLC, and MS to ensure identity, potency, and suitability as an internal standard. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for purity, isotopic enrichment, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.