Description

3,4-Dimethoxy[7,8,9,-13C3]-Cinnamic Acid is a stable isotope-labeled analog of a key cinnamic acid derivative, where three specific carbon atoms are enriched with the non-radioactive carbon-13 isotope. This compound is essential for advanced analytical applications requiring high precision and sensitivity, serving as a critical internal standard for quantitative mass spectrometry. It is primarily utilized by research institutions, pharmaceutical developers, and CROs engaged in metabolic pathway tracing, pharmacokinetic studies, and the development of validated bioanalytical methods.

Application

• Quantitative Mass Spectrometry (MS) Internal Standard: Essential for accurate quantification of unlabeled 3,4-dimethoxycinnamic acid and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds in preclinical and clinical research.
• Metabolic Pathway Analysis: Enables precise tracking and elucidation of biochemical pathways in plant, microbial, and mammalian systems due to its isotopic label.
• Bioanalytical Method Development and Validation: Critical for developing robust, GLP/GMP-compliant LC-MS/MS methods, ensuring data integrity and regulatory acceptance.
• Stable Isotope Dilution Assays (SIDA): Provides the highest accuracy in quantifying target analytes in food chemistry, environmental analysis, and clinical diagnostics.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	3,4-Dimethoxy[7,8,9,-13C3]-Cinnamic Acid
CAS No.	1185241-38-6
Molecular Formula	C11H1213C3O4
Molecular Weight	~225.20 g/mol (for 13C3 labeled form)
Synonyms	(2E)-3-(3,4-Dimethoxyphenyl)-2-propenoic-7,8,9-13C3 acid; 3,4-Dimethoxycinnamic-7,8,9-13C3 Acid; Caffeic Acid Dimethyl Ether-13C3; (E)-3-(3,4-Dimethoxyphenyl)acrylic-7,8,9-13C3 Acid; Labeled Sinapic Acid Isomer; 3,4-Dimethoxy-[13C3]-Cinnamic Acid; Stable Isotope Labeled 3,4-Dimethoxycinnamate
EINECS	Contact for details

Quality Control

Every batch of our 3,4-Dimethoxy[7,8,9,-13C3]-Cinnamic Acid is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity by HPLC, and confirmation of structure by NMR and MS. Our quality systems support compliance with the standards required for GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to maintain isotopic integrity and prevent contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% on labeled positions
Chemical Purity (by 1H NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.