Description

Dacarbazine-D6 is a deuterated isotopologue of the chemotherapeutic agent dacarbazine, specifically labeled with six deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors who require precise analytical measurements for drug development and bioanalytical method validation.

Application

• Primary use as an internal standard for the quantification of dacarbazine in biological matrices via LC-MS/MS and GC-MS.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies in preclinical and clinical research.
• Enables high-precision bioanalytical method development and validation in compliance with FDA and ICH guidelines.
• Supports metabolite identification and pathway analysis in mechanistic toxicology studies.
• Used in quality control laboratories for the assay of dacarbazine in pharmaceutical formulations.
• Critical for stable isotope dilution analysis (SIDA) to achieve superior accuracy in complex sample analysis.

Basic Information

Product Name	Dacarbazine-D6
CAS No.	1185241-28-4
Molecular Formula	C6H4D6N6O
Molecular Weight	188.21 g/mol
Synonyms	5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide-d6; DTIC-D6; Dacarbazine hexadeuterated; Imidazole Carboxamide-d6; 4-(Dimethyltriazeno)imidazole-5-carboxamide-d6; NSC 45388-d6; WR-139007-d6; Deuterated Dacarbazine
EINECS	Contact for details

Quality Control

Our Dacarbazine-D6 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity, and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled compounds, and our quality commitment ensures reliable and reproducible performance in your critical research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.