Description

Hymenialdisine-D4 is a deuterated analog of the natural marine sponge alkaloid Hymenialdisine, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is a critical tool for biomedical research, particularly in the study of kinase inhibition pathways and drug metabolism. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) engaged in advanced pharmacokinetic and proteomic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate bioanalysis of Hymenialdisine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and quantifying the parent drug and its metabolites in in vitro and in vivo studies.
• Kinase Inhibitor Research: Acts as a deuterated probe in mechanistic studies targeting glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinases (CDKs).
• Proteomics and Biomarker Discovery: Employed in stable isotope labeling techniques for relative and absolute quantification in protein interaction studies.
• Pharmaceutical Reference Standard: Provides a certified, high-purity material for method development, validation, and quality control of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Hymenialdisine-D4
CAS No.	1185240-30-5
Molecular Formula	C₁₁H₇D₄N₅O₂
Molecular Weight	233.25 g/mol (approx.)
Synonyms	Hymenialdisine-d4; 2-((2-Amino-3H-purin-6-yl)amino)-5-(dideuteriomethylene)-4-(dideuteriomethylene)-4,5-dihydro-1H-imidazol-4-one; Deuterated Hymenialdisine; GSK-3β Inhibitor-d4; Isotopically Labeled Hymenialdisine
EINECS	Contact for details

Quality Control

Our Hymenialdisine-D4 is manufactured under strict quality management systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity, and identity confirmation. We adhere to relevant guidelines for the production of stable isotope-labeled compounds for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storage at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (H-NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.