Description

Trans,trans-Muconic Acid-D4 is a deuterium-labeled isotopologue of the important dicarboxylic acid, muconic acid. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by researchers and quality control laboratories in the pharmaceutical, environmental, and biochemical sectors for precise metabolic pathway analysis, biomarker quantification, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of muconic acid and related metabolites in complex biological matrices like urine, plasma, and tissue samples.
• Metabolomics Research: Used in stable isotope dilution assays to study benzene exposure biomarkers and the catabolic pathways of aromatic compounds in biological systems.
• Pharmaceutical Development: Facilitates precise drug metabolism and pharmacokinetic (DMPK) studies for compounds metabolized through aromatic ring cleavage pathways.
• Environmental Analysis: Enables the sensitive tracking and quantification of pollutant degradation intermediates in environmental samples.
• Biochemical Pathway Tracing: Serves as a labeled tracer in research focused on the microbial and enzymatic degradation of lignin and other aromatic polymers.
• Quality Control & Method Validation: Essential for developing and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA) for clinical and forensic toxicology.

Basic Information

Product Name	Trans,trans-Muconic Acid-D4
CAS No.	1185239-59-1
Molecular Formula	C6H2D4O4
Molecular Weight	170.15 g/mol
Synonyms	(2E,4E)-Hexa-2,4-dienedioic-2,3,4,5-d4 acid; Muconic Acid-d4; Deuterated trans,trans-Muconic Acid; 2,4-Hexadienedioic-2,3,4,5-d4 acid (trans,trans-); Benzene-cis,cis-dihydrodiol dehydrogenase substrate-d4; Isotopically Labeled Muconic Acid; Internal Standard for S-PMA analysis; tt-MA-d4
EINECS	Contact for details

Quality Control

Our Trans,trans-Muconic Acid-D4 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Each batch is characterized by NMR (¹H, ²H) and High-Resolution Mass Spectrometry (HRMS) to confirm structure and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and other critical parameters is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.