Description

p-Aminophenylacetic-D4 Acid is a high-purity, deuterium-labeled derivative of p-aminophenylacetic acid, a key building block in organic synthesis. This isotopically labeled compound is essential for creating internal standards used in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of p-aminophenylacetic acid and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in tracing metabolic pathways, studying pharmacokinetics, and identifying metabolites during preclinical and clinical development of new chemical entities.
• Bioanalytical Method Development: Enables the development and validation of robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Stable Isotope Labeling: Acts as a precursor for synthesizing more complex deuterated molecules for use in various mechanistic and tracer studies.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and ensures batch-to-batch consistency in API manufacturing where p-aminophenylacetic acid is an intermediate.
• Academic and Industrial Research: Facilitates research in medicinal chemistry, chemical biology, and proteomics where isotopic labeling is required.

Basic Information

Product Name	p-Aminophenylacetic-D4 Acid
CAS No.	1185174-46-2
Molecular Formula	C8H5D4NO2
Molecular Weight	155.18 g/mol (approx.)
Synonyms	(4-Aminophenyl)acetic-2,2-d2 acid-d2; 4-Aminobenzeneacetic-d4 acid; p-Aminophenyl-d4-acetic acid; Deuterated p-Aminohippuric Acid precursor; 2-(4-Aminophenyl)acetic-2,2,2-d3 acid-d; 4-Amino-benzeneacetic-d4 acid; [2H4]-4-Aminophenylacetic Acid; (4-Aminophenyl-d4)acetic Acid
EINECS	Contact for details

Quality Control

Our p-Aminophenylacetic-D4 Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm isotopic purity (≥98 atom % D) and chemical purity (≥95%). Certificates of Analysis (COA) detailing all specifications are provided and traceable to internationally recognized reference standards, supporting compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.