Description

Chlorzoxazone-D3 is a deuterium-labeled analog of the centrally acting muscle relaxant chlorzoxazone, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is essential for ensuring the accuracy, precision, and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories who require high-purity reference materials for method development, validation, and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of chlorzoxazone in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Method Development and Validation: Used as a reference material to develop, optimize, and validate robust bioanalytical methods according to regulatory guidelines (e.g., FDA, EMA).
• Drug Metabolism Research: Facilitates studies on the metabolic pathways and stability of chlorzoxazone without interference from endogenous compounds.
• Quality Control in Manufacturing: Supports impurity profiling and assay verification in the production of chlorzoxazone active pharmaceutical ingredients (APIs).
• Forensic and Doping Control Analysis: Provides a reliable reference for the detection and confirmation of chlorzoxazone in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Chlorzoxazone-D3
CAS No.	1185173-60-7
Molecular Formula	C7H3D3ClN2O2
Molecular Weight	172.60 g/mol (for C7H3D3ClN2O2)
Synonyms	5-Chloro-2(3H)-benzoxazolone-D3; 5-Chloro-2-hydroxybenzoxazole-D3; Chlorzoxazone (phenyl-D3); 5-Chloro-2-benzoxazolinone-D3; Paraflex-D3; Solaxin-D3; Muscol-D3; Chlorzoxazon-D3
EINECS	Contact for details

Quality Control

Our Chlorzoxazone-D3 is manufactured under strict quality systems to ensure it meets the exacting requirements for use as an analytical reference standard. Each batch undergoes comprehensive testing, including isotopic purity assessment by NMR and mass spectrometry, chemical purity determination by HPLC, and confirmation of structure. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We adhere to relevant industry standards to support your compliance needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.