Description

Methyl 2-(4’-Acetyl-2-Fluoro-Biphenyl-4-Yl)-Propionate-D3 is a deuterated isotopologue of a key biphenyl derivative, offering a stable, non-radioactive label for advanced research and development. This compound is specifically engineered to serve as a critical internal standard or labeled intermediate in quantitative analytical methods and metabolic studies. It is primarily utilized by pharmaceutical researchers and analytical chemists in the development and validation of high-precision assays for novel drug candidates.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of active pharmaceutical ingredients (APIs) and their metabolites.
• Deuterated Synthetic Intermediate: Used in the synthesis of deuterium-labeled drug molecules for pharmacokinetic (PK), pharmacodynamic (PD), and absorption, distribution, metabolism, and excretion (ADME) studies.
• Metabolic Pathway Tracing: Enables detailed investigation of drug metabolism and biotransformation pathways due to its isotopic label, providing insights into metabolic stability and potential drug-drug interactions.
• Analytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with ICH Q2(R1) guidelines, ensuring data integrity in regulatory submissions.
• Biomedical Research: Supports non-clinical research in academia and industry for studying the behavior of biphenyl-based compounds in biological systems.

Basic Information

Product Name	Methyl 2-(4’-Acetyl-2-Fluoro-Biphenyl-4-Yl)-Propionate-D3
CAS No.	1185157-06-5
Molecular Formula	C₁₉H₁₅D₃FO₃
Molecular Weight	316.36 g/mol
Synonyms	Methyl 2-(4'-Acetyl-2-fluorobiphenyl-4-yl)propionate-d3; 2-(4'-Acetyl-2-fluoro[1,1'-biphenyl]-4-yl)propanoic-3,3,3-d3 acid methyl ester; Deuterated Methyl Flurbiprofen Acetyl Derivative; [D3]-Methyl 2-(4'-Acetyl-2-fluorobiphenyl-4-yl)propionate; Methyl 2-(4'-Acetyl-2-fluoro-1,1'-biphenyl-4-yl)-3,3,3-trideuteriopropanoate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4’-Acetyl-2-Fluoro-Biphenyl-4-Yl)-Propionate-D3 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from NMR (¹H, ¹³C), mass spectrometry, and HPLC analysis. We adhere to cGMP principles for research chemicals, ensuring traceability, consistency, and reliability for your critical development work.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under inert atmosphere for long-term stability. The compound is moisture-sensitive; keep the container in a dry environment and allow it to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98.0 atom % D
Chemical Purity (¹H NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.