Description

2-n-Propyl-4-Methyl-6-(1-Methylbenzimidazol-2-Yl)-Benzimidazole-D3 is a deuterated benzimidazole derivative, a high-value specialty chemical used as a stable isotope-labeled internal standard. This compound is critical for ensuring the accuracy and reliability of quantitative analytical methods, particularly in regulated environments. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers for applications in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard in liquid chromatography-tandem mass spectrometry for the precise quantification of its non-deuterated counterpart or related benzimidazole compounds.
• Pharmaceutical Bioanalysis: Essential in method development and validation for measuring drug concentrations in biological matrices (plasma, serum, urine) during preclinical and clinical trials.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• DMPK Studies: Supports drug discovery and development by enabling accurate pharmacokinetic parameter calculation, including absorption, distribution, metabolism, and excretion (ADME).
• Reference Material: Serves as a certified reference material (CRM) or high-purity standard for calibrating analytical instruments and ensuring data integrity.
• Regulatory Submissions: Provides the traceable and consistent standard required for data packages submitted to regulatory bodies like the FDA and EMA.

Basic Information

Product Name	2-n-Propyl-4-Methyl-6-(1-Methylbenzimidazol-2-Yl)-Benzimidazole-D3
CAS No.	1185154-60-2
Molecular Formula	C19H17D3N4
Molecular Weight	307.41 g/mol (approx.)
Synonyms	2-Propyl-4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-1H-benzimidazole-d3; 2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-d3; Deuterated Benzimidazole Internal Standard; [D3]-Labeled Benzimidazole Derivative; 2-(1-Methyl-1H-benzimidazol-2-yl)-4-methyl-6-propyl-1H-benzimidazole-d3; CAS 1185154-60-2; Stable Isotope Labeled Standard
EINECS	Contact for details

Quality Control

Every batch of 2-n-Propyl-4-Methyl-6-(1-Methylbenzimidazol-2-Yl)-Benzimidazole-D3 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical science. Comprehensive testing includes assay, isotopic enrichment (D-content), and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.