Description

Olmesartan-D6 Acid is a high-purity, isotopically labeled internal standard critical for ensuring analytical accuracy in quantitative bioanalysis. This deuterated compound is essential for researchers and quality control laboratories requiring precise and reliable measurement of the antihypertensive drug olmesartan in complex biological matrices. It is primarily utilized in pharmaceutical research, drug metabolism and pharmacokinetics (DMPK) studies, and clinical trial support within the global life sciences sector.

Application

• Quantitative Bioanalytical Internal Standard: Used in LC-MS/MS and GC-MS methods for the accurate quantification of olmesartan in plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a critical tool in studying the absorption, distribution, metabolism, and excretion (ADME) profile of olmesartan.
• Clinical Trial Analysis: Enables precise measurement of drug concentration in patient samples during clinical development and therapeutic drug monitoring.
• Pharmaceutical Quality Control: Applied in impurity profiling and assay validation for olmesartan active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Anti-Doping Analysis: Supports the detection and confirmation of olmesartan in forensic toxicology and sports doping control.
• Stable Isotope Labeling Studies: Used as a tracer in metabolic pathway research and mechanistic studies.

Basic Information

Product Name	Olmesartan-D6 Acid
CAS No.	1185144-74-4
Molecular Formula	C₂₉H₂₄D₆N₆O₆
Molecular Weight	552.62 g/mol
Synonyms	Olmesartan-d6; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid-d6; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2,2-dideuterio-2-phenylethyl)piperazine-1-carboxylate-d4; Deuterated Olmesartan Acid; Olmesartan (D6) Acid; Isotopically Labeled Olmesartan Acid; Internal Standard for Olmesartan Assay
EINECS	Contact for details

Quality Control

Our Olmesartan-D6 Acid is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium enrichment. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.