Description

n-(4-Amino-6,7-Dimethoxyquinazol-2-Yl)-n-Methyl-D3-2-Cyanoethylamine is a deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled building block, enabling the creation of deuterated drug candidates with potentially improved metabolic profiles and pharmacokinetic properties. This compound is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the synthesis of novel therapeutics, particularly in oncology and other targeted therapy areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of deuterated active pharmaceutical ingredients (APIs) and drug candidates.
• Metabolic Stability Studies: Used in the development of deuterium-labeled compounds to study and potentially slow down drug metabolism (deuterium kinetic isotope effect).
• Internal Standards for Bioanalysis: Serves as a precursor for synthesizing stable isotope-labeled internal standards used in Liquid Chromatography-Mass Spectrometry (LC-MS) for accurate quantification in biological matrices.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a deuterated analog of key quinazoline-based pharmacophores.
• Preclinical Drug Development: Utilized in the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology evaluations.
• Proteomics & Chemical Biology: Potential use as a tagged molecule or probe in chemical proteomics to study protein-ligand interactions.

Basic Information

Product Name	n-(4-Amino-6,7-Dimethoxyquinazol-2-Yl)-n-Methyl-D3-2-Cyanoethylamine
CAS No.	1185144-54-0
Molecular Formula	C₁₄H₁₄D₃N₅O₂
Molecular Weight	288.34 g/mol
Synonyms	2-[[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methyl-d3-amino]acetonitrile; N-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-(methyl-d3)-2-cyanoethylamine; 2-((4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl-d3)amino)acetonitrile; Deuterated Afatinib Intermediate; D3-Afatinib Intermediate; N-Methyl-D3-2-Cyanoethylamine Quinazoline Derivative; 4-Amino-6,7-dimethoxy-2-[[(methyl-d3)(2-cyanoethyl)amino]methyl]quinazoline
EINECS	Contact for details

Quality Control

Our deuterated intermediates are produced under strict quality control protocols to ensure high chemical purity and isotopic enrichment, critical for research integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ²H), High-Performance Liquid Chromatography (HPLC), and Mass Spectrometry (MS). A comprehensive Certificate of Analysis (COA) detailing purity, assay, isotopic purity (D-content), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR)	≥ 98 atom % D (at labeled positions)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.