Description

Flurbiprofen-D3 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen, where three hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise quantification of flurbiprofen in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of flurbiprofen.
• Bioequivalence and Clinical Trials: Enables accurate measurement of flurbiprofen concentrations in plasma, serum, or urine during clinical research.
• Forensic and Toxicological Analysis: Supports accurate quantification in forensic toxicology for cases involving flurbiprofen.
• Pharmaceutical Quality Control: Can be utilized in advanced analytical methods for impurity profiling and assay validation of flurbiprofen API and formulations.

Basic Information

Product Name	Flurbiprofen-D3
CAS No.	1185133-81-6
Molecular Formula	C15H10D3FO2
Molecular Weight	247.29 g/mol
Synonyms	Flurbiprofen-d3; [2-Fluoro-α-methyl(1,1,1-2H3)-[1,1'-biphenyl]-4-acetic acid; 2-(2-Fluoro-4-biphenylyl)propionic-3,3,3-d3 acid; (±)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic-3,3,3-d3 acid; (RS)-2-(2-Fluorobiphenyl-4-yl)propionic-3,3,3-d3 acid; Deuterated Flurbiprofen; Flurbiprofen Internal Standard
EINECS	Contact for details

Quality Control

Our Flurbiprofen-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is thoroughly characterized and tested. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by MS), and identification. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.