Description

Ethyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(Methylsulfonyl)Pyrimidine-5-Carboxylate-D6 is a deuterated isotopologue of a key pyrimidine derivative, serving as a critical building block and stable isotope-labeled standard in advanced chemical synthesis. Its primary value lies in enabling precise analytical quantification and metabolic pathway tracing in pharmaceutical research and development. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors who require deuterium-labeled internal standards for mass spectrometry, pharmacokinetic studies, and the development of novel active ingredients.

Application

• Deuterated Internal Standard for LC-MS/MS: Used as a quantitative reference standard in bioanalytical methods for drug metabolism and pharmacokinetic (DMPK) studies.
• Pharmaceutical Intermediate: Acts as a labeled precursor in the synthesis of deuterated drug candidates, potentially enhancing metabolic stability.
• Metabolic Pathway Tracing: Facilitates the study of absorption, distribution, metabolism, and excretion (ADME) of parent compounds in biological systems.
• Agrochemical Research: Employed in the development and analysis of novel pyrimidine-based pesticides and herbicides.
• Chemical Reference Material: Provides a certified standard for quality control and method validation in analytical laboratories.
• Isotope Labeling Studies: Supports research in mechanistic organic chemistry and reaction pathway elucidation.

Basic Information

Product Name	Ethyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(Methylsulfonyl)Pyrimidine-5-Carboxylate-D6
CAS No.	1185128-49-7
Molecular Formula	C₁₇H₁₃D₆FNO₄S
Molecular Weight	~357.41 g/mol
Synonyms	Ethyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(Methylsulfonyl)Pyrimidine-5-Carboxylate-d6; 2-(Methylsulfonyl)-4-(4-fluorophenyl)-6-(1-methylethyl)-5-pyrimidinecarboxylic Acid Ethyl Ester-d6; Deuterated Atorvastatin Intermediate-d6; 4-(4-Fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylic Acid Ethyl Ester-d6; [D6]-Ethyl 4-(4-Fluorophenyl)-6-Isopropyl-2-(Methylsulfonyl)Pyrimidine-5-Carboxylate; Ethyl 4-(p-Fluorophenyl)-6-isopropyl-2-(methylsulfonyl)-5-pyrimidinecarboxylate-d6; Atorvastatin-d6 Ethyl Ester Derivative; 1185128-49-7
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure high isotopic purity and chemical integrity. Each batch undergoes comprehensive analysis, including HPLC, NMR, and mass spectrometry, to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing lot-specific results are provided and traceable to relevant standards. We support compliance needs for research under GLP and cGMP frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is moisture-sensitive; keep the original container tightly sealed under inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and isotopic purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.